粘膜相關(guān)**組織**瘤轉(zhuǎn)運(yùn)蛋白1抗體
規(guī)格：1mg/1ml
英文名： MALT1
別名： Caspase like protein; DKFZp434L132; MALT 1; MALT associated translocation; MALT lymphoma associated translocation; MALT lymphoma-associated translocation; Malt1; MALT1_HUMAN; MLT 1; MLT; MLT1; Mucosa
分子量： 91kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human MALT1
交叉反應(yīng)：Human, Mouse, Rat, Chicken, Horse, Sheep,
細(xì)胞定位：細(xì)胞核 細(xì)胞漿
粘膜相關(guān)**組織**瘤轉(zhuǎn)運(yùn)蛋白1抗體產(chǎn)品介紹：background: This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]. Function: Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity. MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Subunit: Binds through its Ig-like domains to BCL10. Forms oligomers which bind to TRAF6. Subcellular Location: Cytoplasm, perinuclear region. Nucleus. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10. Tissue Specificity:粘膜相關(guān)**組織**瘤轉(zhuǎn)運(yùn)蛋白1抗體 Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. DISEASE: Note=A chromosomal aberration involving MALT1 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with BIRC2. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma. Similarity: Belongs to the peptidase C14B family. Contains 1 death domain粘膜相關(guān)**組織**瘤轉(zhuǎn)運(yùn)蛋白1抗體. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Gene ID: 10892 Database links: Entrez Gene: 10892 Human Entrez Gene: 240354 Mouse Omim: 604860 Human SwissProt: Q9UDY8 Human SwissProt: Q2TBA3 Mouse Unigene: 601217 Human Unigene: 132613 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)粘膜相關(guān)**組織**瘤轉(zhuǎn)運(yùn)蛋白1抗體品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞凋亡 轉(zhuǎn)錄調(diào)節(jié)因子
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid