鋅指蛋白521抗體
規(guī)格：1mg/1ml
英文名： ZNF521
別名： Early hematopoietic zinc finger; Early hematopoietic zinc finger protein; EHZF; Evi3; LYST-interacting protein 3; MGC142182; Zfp521; Zinc finger protein 521; ZN521_HUMAN; Znf521.
分子量： 148kDa
儲存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human EHZF/ZN5
交叉反應：Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
細胞定位：細胞核
鋅指蛋白521抗體產(chǎn)品介紹：background: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. Function: Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. Subunit: Interacts with EBF1. Interacts with SMAD1 and SMAD4. Subcellular Location: Nucleus. 鋅指蛋白521抗體Tissue Specificity: Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins. DISEASE: Note=A chromosomal aberration involving ZNF521 is found in acute lymphoblastic leukemia. Translocation鋅指蛋白521抗體 t(9;18)(p13;q11.2) with PAX5. The translocation generates the PAX5-ZNF521 oncogene consisting of the N-terminus part of PAX5 and the C-terminus part of ZNF521. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 30 C2H2-type zinc fingers. Database links: Entrez Gene: 25925 Human Omim: 610974 Human SwissProt: Q96K83 Human Unigene: 116935 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
鋅指蛋白521抗體產(chǎn)品應用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領域：細胞生物 **學 信號轉導 鋅指蛋白 表觀遺傳學
儲存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid